Sjogren’s, Type I Diabetes, Celiac, Ulcerative Colitis and Crohn’s Disease
I. Immunity Review
a. First Line of Defense includes intact skin and mucus membranes as well as cilia, mucus, acid mantle and saliva
b. Second Line of Defense include phagocytes, NK cells, inflammatory response and antimicrobial proteins
c. Adaptive Defenses
i. Specific, systemic and have memory
ii. Antibody mediated & cell mediated
iii. Cells of the system
1. B Lymphocytes produce antibodies (Ig G. Ig A. Ig E. Ig M. Ig D)
2. T Lymphocytes
3. APC
iv. Maturation includes immunocompetence and self-tolerance
II. Autoimmunity
a. Defined
b. Comorbidity
c. Common autoimmune disease with dental implications
i. Sjogren’s
1. Prevalence and symptomology
2. Treatments
3. Oral manifestations and complications
ii. Type I diabetes
1. Prevalence and symptomology
2. Treatments
3. Oral manifestations and complications
iii. Celiac Disease
1. Prevalence and symptomology
2. Treatment
3. Oral manifestations and complications
a. Herpetiform ulcerations
b. Enamel defects
c. Cheilosis
d. Oral lichen planus
e. Delay eruption
f. Atrophic glossitis
d. Common auto-immune disease that effect the gut and eating habits
i. Ulcerative colitis
1. Prevalence
2. Treatment
3. Oral implications
ii. Crohn’s Disease
1. Prevalence
2. Treatments
3. Oral Implications
III. Special Treatment Considerations
a. Product avoidance
b. Product recommendations
c. Clinical Modifications